「化学方块」为建造新药物和农药带来新工具
一个基于立方分子的化学创建平台正在被发掘中，这可能有助于让疲惫的药物和农药重获新生。
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昆士兰大学的Craig Williams教授表示，这个平台是与CSIRO合作开发的，为许多化学家提供了一套令人兴奋的工具，这些化学家在很多情况下已经没有新的化学构建方块选项。
「历史上，化学家经常依赖碳氢化合物，如石油化学品，来建造对社会至关重要的新化学物质。」Williams教授说。
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「但是，一个关键的碳氢化合物一直被忽视，那就是以立方体为形状的合成碳氢化合物，就是方块烷(cubane)。
「方块烷以前被忽视了，因为没有方法在大规模上合成这个分子，因此它的应用是有限的。
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但现在已经有所改变了，澳大利亚CSIRO的化学家报告了一个千克级别的合成，现在在墨尔本的Boron Molecular中生产，使得在21世纪有了方块烷的大量研究。 」
UQ团队首次成功地将一个氮原子纳入到方块烷的近亲中，这可能有助于长期改善这一类分子在生物系统中的性质。
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Williams教授说:「碳氢化合物在广泛的药物中取得了成功，但是纯碳原子核心的性质会阻碍一些生物反应并限制它们在药物和农药发现中的应用。」
「像氮这样的元素可以促进生物上的理想互动，这是碳氢化合物所没有的。
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「事实上，氮的生物需求如此之大，以至于大多数得到美国FDA批准的药物中至少包含一个氮原子。将氮原子替换到药理学上证明的碳氢化合物支架中，就像方块烷一样，这是一种未足取得使用但是有吸引力的策略，可升级其生物潜力。」
「在与芝加哥大学和昆士兰理工大学的合作中，合成和研究1-aza-homocubane推动了成果的极限。」
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Williams教授与CSIRO制造部门副主任Paul Savage博士多年合作，Savage博士的团队擅长将实验室的发明转化为可伸缩的过程。
Savage博士表示该研究团队对未来充满期待。
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「这一基础工作可能会带
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